Bioconversion of black rice and blueberry regulate immunity system through regulation of MAPKs, NF-kB in RAW264.7 macrophage cells

Bioconversion can enhance the functionality of efficacy. We made bioconversion material with black rice (Oryza sativa L.) and blueberry (Vaccinium crymbosum L.), using Lactobacillus plantarum (call BB). In this study, BB investigated anti-inflammatory immune-boosting effects through immune system control. Therefore, we efficacy in presence absence LPS (Lipopolysaccharide). LPS, inhibited nitric oxide (NO) production from macrophages, inducible synthase (iNOS), Cyclooxygenase 2 (COX-2), phosphorylation mitogen-activated protein kinases (such as JNK, ERK p-38) reduced secretion cytokines Tumor necrosis factor-α (TNF-α) Interleukin-6 (IL-6). exhibited an effect that was opposite stimulation. These data show lower than LPS. conclusion, suggested regulation are multi-efficacy materials.